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Contributor: By loosening standards, the FDA isn't doing rare-disease patients any favors

It's reasonable to assess rare-disease drugs differently. That's why the FDA has been remarkably flexible about these approvals for decades. But some treatments just aren't any good.

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Opinions

SARAH VINE: If we fall for Kim Kardashian's £34 dead rat it's proof we've really lost it

SARAH VINE: If we fall for Kim Kardashian's £34 dead rat it's proof we've really lost it

about 13 hours ago

MAIL ON SUNDAY COMMENT: The prince wriggled and squirmed... but a free and fearless Press would not let him off the hook

MAIL ON SUNDAY COMMENT: The prince wriggled and squirmed... but a free and fearless Press would not let him off the hook

about 14 hours ago

FLOURISHING AFTER 50: I'm 58 and just lost my job - I'm terrified no one will hire me again

FLOURISHING AFTER 50: I'm 58 and just lost my job - I'm terrified no one will hire me again

about 18 hours ago

Trump should box Putin in BEFORE any Budapest showdown

Trump should box Putin in BEFORE any Budapest showdown

about 19 hours ago

Mamdani’s pathetic plans for NYC schools prove he doesn’t really want to govern the city at all

Mamdani’s pathetic plans for NYC schools prove he doesn’t really want to govern the city at all

about 19 hours ago

My wife always swore she didn't masturbate. Then I caught her in the act doing something so shocking, I can barely look her in the eye: ASK JANA

My wife always swore she didn't masturbate. Then I caught her in the act doing something so shocking, I can barely look her in the eye: ASK JANA

about 21 hours ago

'He'll never be PM': In unsparing detail, Cabinet sources tell PVO of Jim Chalmers' private humiliation over his super tax backdown, his denial until the last moment... and Albo's Shakespearean betrayal

'He'll never be PM': In unsparing detail, Cabinet sources tell PVO of Jim Chalmers' private humiliation over his super tax backdown, his denial until the last moment... and Albo's Shakespearean betrayal

about 21 hours ago

ALEXANDRA SHULMAN'S NOTEBOOK: After cancer, Kate's house move really is a new start

ALEXANDRA SHULMAN'S NOTEBOOK: After cancer, Kate's house move really is a new start

about 21 hours ago

DAN HODGES: This is who Cabinet ministers have told me is REALLY to blame for Labour's China crisis... and some Foreign Office officials are even calling her the 'Dragon Lady'

DAN HODGES: This is who Cabinet ministers have told me is REALLY to blame for Labour's China crisis... and some Foreign Office officials are even calling her the 'Dragon Lady'

about 21 hours ago

PETER HITCHENS: It's Left-wingers who should worship Maggie. She's no idol for REAL conservatives

PETER HITCHENS: It's Left-wingers who should worship Maggie. She's no idol for REAL conservatives

about 21 hours ago

KENNEDY: Here's the truth of weird drug-fueled orgies in Congress that Tucker Carlson is investigating... it makes me sick to my stomach

KENNEDY: Here's the truth of weird drug-fueled orgies in Congress that Tucker Carlson is investigating... it makes me sick to my stomach

about 21 hours ago

The war on pet stores and more: Letters to the Editor — Oct. 19, 2025

The war on pet stores and more: Letters to the Editor — Oct. 19, 2025

about 22 hours ago

Letters to the Editor: Plan to prevent fires with fuel breaks is 'counterproductive and harmful'

Letters to the Editor: Plan to prevent fires with fuel breaks is 'counterproductive and harmful'

about 22 hours ago

BEL MOONEY: How can I stop family parading snaps of my kids online?

BEL MOONEY: How can I stop family parading snaps of my kids online?

The day I dined with the Muhammad Ali of sumo wrestling - this is how the great champion feasted: JEFF POWELL

The day I dined with the Muhammad Ali of sumo wrestling - this is how the great champion feasted: JEFF POWELL

Dear Abby: I know my sister is stealing from me, but she won’t admit it

Dear Abby: I know my sister is stealing from me, but she won’t admit it

ALEX BRUMMER: I've just met the world's top financiers and they're terrified. A catastrophic crash that will destroy savings, prosperity and living standard is coming. Britain's in deep, deep trouble

ALEX BRUMMER: I've just met the world's top financiers and they're terrified. A catastrophic crash that will destroy savings, prosperity and living standard is coming. Britain's in deep, deep trouble

'Insane, thoughtless and directionless. The Sussexes are spiralling': Insider's damning words to ALISON BOSHOFF on Meghan's latest reinvention as they reveal 'mess' - and her very surprising next move

'Insane, thoughtless and directionless. The Sussexes are spiralling': Insider's damning words to ALISON BOSHOFF on Meghan's latest reinvention as they reveal 'mess' - and her very surprising next move

International treasure hunt for Lady Gabriella husband's missing cash: RICHARD EDEN

International treasure hunt for Lady Gabriella husband's missing cash: RICHARD EDEN

QUENTIN LETTS: Fortune is turning against the silken, sinuous courtier blamed for the China spy scandal. So will Keir Starmer sever the suppurating limb that is National Security Adviser Jonathan Powell?

QUENTIN LETTS: Fortune is turning against the silken, sinuous courtier blamed for the China spy scandal. So will Keir Starmer sever the suppurating limb that is National Security Adviser Jonathan Powell?

The Bill Belichick trainwreck just keeps getting worse, and we all know who’s pulling the levers

The Bill Belichick trainwreck just keeps getting worse, and we all know who’s pulling the levers

DAILY MAIL COMMENT: It took a long time coming, but Prince Andrew has finally done the right thing

DAILY MAIL COMMENT: It took a long time coming, but Prince Andrew has finally done the right thing

Why John Bolton probably WON’T pay big if found guilty in his documents case

Why John Bolton probably WON’T pay big if found guilty in his documents case

ALEX BRUMMER: Britain suffering inflation calamity

ALEX BRUMMER: Britain suffering inflation calamity

Game of thongs! My bizarre night with the sumo superfans by ROBERT HARDMAN

Game of thongs! My bizarre night with the sumo superfans by ROBERT HARDMAN

Winning World War III, ‘vision thing’ dooms Democrats and other commentary

Winning World War III, ‘vision thing’ dooms Democrats and other commentary

Sick Young Republican group chat is part of the right’s new ‘vice signaling’ bonding ritual

Sick Young Republican group chat is part of the right’s new ‘vice signaling’ bonding ritual

Why Trump is succeeding in the Middle East where Biden and Obama failed

Why Trump is succeeding in the Middle East where Biden and Obama failed

Mamdani’s debate lies, dodges and fumbles — signs of disaster ahead for NYC

Mamdani’s debate lies, dodges and fumbles — signs of disaster ahead for NYC

The disastrous NYC mayoral debate: Letters to the Editor — Oct. 18, 2025

The disastrous NYC mayoral debate: Letters to the Editor — Oct. 18, 2025

A key psychiatric group censored our doctors for seeking to discuss the harm of child sex changes

A key psychiatric group censored our doctors for seeking to discuss the harm of child sex changes

Dems’ biggest problem isn’t Mamdani and socialists — it’s the ‘moderates’ who cave to them

Dems’ biggest problem isn’t Mamdani and socialists — it’s the ‘moderates’ who cave to them

AMANDA PLATELL: Meghan's own goal of monumental stupidity is the kind only she is capable of making

AMANDA PLATELL: Meghan's own goal of monumental stupidity is the kind only she is capable of making

Letters to the Editor: Ballot conspiracy claim is easily debunked, at least in L.A. County

Letters to the Editor: Ballot conspiracy claim is easily debunked, at least in L.A. County

BORIS JOHNSON: Britain is enduring a slow-motion catastrophe, as one set of tax rises triggers the next. There's only one solution

BORIS JOHNSON: Britain is enduring a slow-motion catastrophe, as one set of tax rises triggers the next. There's only one solution

Hilaria Baldwin may be out of DWTS, but she’s still going for first place — in the self-pity Olympics

Hilaria Baldwin may be out of DWTS, but she’s still going for first place — in the self-pity Olympics

Celebrate with an “Ocean State of Mind” this festive season

Celebrate with an “Ocean State of Mind” this festive season

Infographic: Moderna’s strategic partnership with the UK government

Infographic: Moderna’s strategic partnership with the UK government

An investment in the future

An investment in the future

We're local park volunteers but Castle Water has demanded a £5,479 bill: CRANE ON THE CASE

We're local park volunteers but Castle Water has demanded a £5,479 bill: CRANE ON THE CASE

Mamdani suffers awful showing in NYC mayoral debate — but Cuomo still can’t bury him

Mamdani suffers awful showing in NYC mayoral debate — but Cuomo still can’t bury him

RICHARD EDEN: Why Petra Ecclestone's husband is on HRT

RICHARD EDEN: Why Petra Ecclestone's husband is on HRT

JAN MOIR: How can soiled Prince Andrew live with himself? And the troubling question: What role did he play in Virginia's death?

JAN MOIR: How can soiled Prince Andrew live with himself? And the troubling question: What role did he play in Virginia's death?

TOM UTLEY: Imagine the furore if Dame Mary Beard had celebrated the demise of 'thicko black rugger buggers' at Cambridge!

TOM UTLEY: Imagine the furore if Dame Mary Beard had celebrated the demise of 'thicko black rugger buggers' at Cambridge!

Phil Murphy’s foolish obsession with wind power has carved a huge opening for Jack Ciatarrelli

Phil Murphy’s foolish obsession with wind power has carved a huge opening for Jack Ciatarrelli

ALISON BOSHOFF: Jacko's daughter reaches out to his 'grooming' victims for the first time

ALISON BOSHOFF: Jacko's daughter reaches out to his 'grooming' victims for the first time

CHRISTOPHER STEVENS reviews The Iris Affair on Sky Atlantic: A wonderfully loopy thriller that pays homage to classic Hitchcock

CHRISTOPHER STEVENS reviews The Iris Affair on Sky Atlantic: A wonderfully loopy thriller that pays homage to classic Hitchcock

Democrat hysteria over the end of racial gerrymandering ignores the reality of racially-mixed America today

Democrat hysteria over the end of racial gerrymandering ignores the reality of racially-mixed America today

Don’t let America become a UK-style antisemitic hell-hole

Don’t let America become a UK-style antisemitic hell-hole

President Trump needs to call out the deadly persecution of Nigerian Christians

President Trump needs to call out the deadly persecution of Nigerian Christians

Hamas’ public executions: Letters to the Editor — Oct. 17, 2025

Hamas’ public executions: Letters to the Editor — Oct. 17, 2025

Good on Trump for targeting Venezuelan drug cartels allied with dictator Nicolás Maduro

Good on Trump for targeting Venezuelan drug cartels allied with dictator Nicolás Maduro

After the Gaza cease-fire, what will these faux revolutionaries protest? Some ideas

After the Gaza cease-fire, what will these faux revolutionaries protest? Some ideas

Wealthy pay a heavy price: Reeves's failure to cut the benefits bill is costing Britain dear, says ALEX BRUMMER

Wealthy pay a heavy price: Reeves's failure to cut the benefits bill is costing Britain dear, says ALEX BRUMMER

This week in whoppers: NY Times calls terrorists ‘hostages,’ Mamdani’s sick fix for bus assaults and more

This week in whoppers: NY Times calls terrorists ‘hostages,’ Mamdani’s sick fix for bus assaults and more

You should think twice before EVER listening to Jamie Dimon: KEVIN O'LEARY'S ultimate takedown of the banking behemoth

You should think twice before EVER listening to Jamie Dimon: KEVIN O'LEARY'S ultimate takedown of the banking behemoth

QUENTIN LETTS: Want to know why Labour has no hope of stopping the small boats? Meet the windy dullard in charge of border security

QUENTIN LETTS: Want to know why Labour has no hope of stopping the small boats? Meet the windy dullard in charge of border security

How a Mayor Mamdani’s Israel hate would twist the entire city

How a Mayor Mamdani’s Israel hate would twist the entire city

BRYONY GORDON: My alopecia left me with a huge bald patch. I tried everything to fix it but this is the only thing that helped my hair grow back... and what actually caused it

BRYONY GORDON: My alopecia left me with a huge bald patch. I tried everything to fix it but this is the only thing that helped my hair grow back... and what actually caused it

Miranda Devine: Trump Derangement Syndrome is on the way out – prez’s alpha-male greatness shines after peace deal

Miranda Devine: Trump Derangement Syndrome is on the way out – prez’s alpha-male greatness shines after peace deal